Supplement reference
TMG (Trimethylglycine / Betaine Anhydrous)
A source-linked reference on TMG (Trimethylglycine / Betaine Anhydrous), evidence, safety and product identity. Sources checked 6 September 2026.
Source and review status
Published sources checked
Sources checked on: 6 September 2026
Qualified clinical review: Pending. This page has not been clinically reviewed.
About this source check
AI-assisted editorial source checking covers the cited material and its stated limits. It is not a systematic review, verification of a supplied product, or clinical sign-off.
Editorial role: InfoAddict. Last material change: 6 September 2026. Next source review: 6 March 2027.
Ingredient and preparation
Trimethylglycine and betaine anhydrous name the same chemical ingredient in many supplement labels.
Sources: National Library of Medicine, PubMed
Evidence and limits
The cited systematic review and meta-analysis concerns betaine and body composition. It does not establish broad methylation, energy, liver-health or exercise claims for trimethylglycine products.
Sources: National Library of Medicine, PubMed
Safety and a useful record
Medicine and health context matter, especially when a product is used in response to a laboratory result. Do not interpret a homocysteine-related claim as medical management.
Sources: National Library of Medicine, PubMed, National Center for Complementary and Integrative Health
Record the chemical name, label amount, reason for use and relevant test details.
Sources: National Center for Complementary and Integrative Health
Published sources
- Betaine supplementation fails to improve body composition: a systematic review and meta-analysis
National Library of Medicine, PubMed. Published 2022; accessed 6 September 2026.
Supports: Systematic review and meta-analysis of betaine supplementation and body-composition outcomes; not a broad methylation or liver-health claim.
- Safe Use of Complementary Health Products and Practices
National Center for Complementary and Integrative Health. Current NCCIH reference; accessed 6 September 2026.
Supports: General safety, interaction and contamination context. It does not establish ingredient-specific benefit.
Change history
| Date | Change | Clinical-review status |
|---|---|---|
| 6 September 2026 | Source-linked reference published | Pending |
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