Supplement reference
Spermidine
A source-linked reference on Spermidine, evidence, safety and product identity. Sources checked 6 September 2026.
Source and review status
Published sources checked
Sources checked on: 6 September 2026
Qualified clinical review: Pending. This page has not been clinically reviewed.
About this source check
AI-assisted editorial source checking covers the cited material and its stated limits. It is not a systematic review, verification of a supplied product, or clinical sign-off.
Editorial role: InfoAddict. Last material change: 6 September 2026. Next source review: 6 March 2027.
Ingredient and preparation
Spermidine is a polyamine present in foods and concentrated products marketed with autophagy or longevity language.
Sources: National Library of Medicine, PubMed
Evidence and limits
A 100-person, 90-day trial of a spermidine-based supplement reported hair-follicle anagen outcomes. It did not test autophagy, longevity or disease prevention, and a multi-ingredient supplement is not equivalent to all spermidine products.
Sources: National Library of Medicine, PubMed
Safety and a useful record
Long-term use and interaction questions are not answered by cellular studies. Product source and actual health context should guide any discussion.
Sources: National Library of Medicine, PubMed, National Center for Complementary and Integrative Health
Record the exact product, stated outcome and other changes rather than assigning a longevity effect to one marker.
Sources: National Center for Complementary and Integrative Health
Published sources
- A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study
National Library of Medicine, PubMed. Published 2017; accessed 6 September 2026.
Supports: A 100-person, 90-day trial of a spermidine-based supplement on hair-follicle outcomes; it does not test longevity or disease prevention.
- Safe Use of Complementary Health Products and Practices
National Center for Complementary and Integrative Health. Current NCCIH reference; accessed 6 September 2026.
Supports: General safety, interaction and contamination context. It does not establish ingredient-specific benefit.
Change history
| Date | Change | Clinical-review status |
|---|---|---|
| 6 September 2026 | Source-linked reference published | Pending |
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