Supplement reference
PQQ (Pyrroloquinoline Quinone)
A source-linked reference on PQQ (Pyrroloquinoline Quinone), evidence, safety and product identity. Sources checked 6 September 2026.
Source and review status
Published sources checked
Sources checked on: 6 September 2026
Qualified clinical review: Pending. This page has not been clinically reviewed.
About this source check
AI-assisted editorial source checking covers the cited material and its stated limits. It is not a systematic review, verification of a supplied product, or clinical sign-off.
Editorial role: InfoAddict. Last material change: 6 September 2026. Next source review: 6 March 2027.
Ingredient and preparation
PQQ is a quinone compound sold in products using mitochondrial or energy language.
Sources: National Library of Medicine, PubMed
Evidence and limits
A 12-week trial randomised 64 healthy Japanese adults to a named PQQ disodium-salt product or placebo; 58 completed. Reported cognitive-test changes are specific to that small trial and formulation, not evidence for energy or healthy-ageing claims.
Sources: National Library of Medicine, PubMed
Safety and a useful record
Long-term safety and interaction questions depend on the actual product and person. Do not treat a proprietary ingredient claim as proof of clinical value.
Sources: National Library of Medicine, PubMed, National Center for Complementary and Integrative Health
Record the full label and a defined outcome rather than broad “energy” or “mitochondrial” marketing language.
Sources: National Center for Complementary and Integrative Health
Published sources
- Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
National Library of Medicine, PubMed. Published 2022; accessed 6 September 2026.
Supports: A 64-person, 12-week trial of a named PQQ disodium-salt product in healthy Japanese adults; the study was small and product-specific.
- Safe Use of Complementary Health Products and Practices
National Center for Complementary and Integrative Health. Current NCCIH reference; accessed 6 September 2026.
Supports: General safety, interaction and contamination context. It does not establish ingredient-specific benefit.
Change history
| Date | Change | Clinical-review status |
|---|---|---|
| 6 September 2026 | Source-linked reference published | Pending |
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