Supplement reference
Berberine
A sourced reference on Berberine identity, evidence limits and safety context.
Source and review status
Published sources checked
Sources checked on: 6 September 2026
Qualified clinical review: Pending. This page has not been clinically reviewed.
About this source check
AI-assisted editorial source checking covers the cited material and its stated limits. It is not a systematic review, verification of a supplied product, or clinical sign-off.
Editorial role: InfoAddict. Last material change: 6 September 2026. Next source review: 6 March 2027.
Identity and product form
Berberine is a substance found in several plants, including goldenseal, barberry and Oregon grape. A product should identify the ingredient and botanical source where applicable.
Sources: National Center for Complementary and Integrative Health
What the reviewed evidence can and cannot show
NCCIH says some studies suggest possible effects on weight measures, but findings were inconsistent, many studies had high risk of bias, products varied, and more high-quality research is needed. This is not a weight-management recommendation.
Sources: National Center for Complementary and Integrative Health
Safety and limits
NCCIH reports gastrointestinal side effects, possible medicine interactions including cyclosporine, and concern for infants, pregnancy and breastfeeding.
Sources: National Center for Complementary and Integrative Health
Published sources
- Berberine: Usefulness and Safety
National Center for Complementary and Integrative Health. Current NIH public information page; accessed 6 September 2026.
Supports: Identity, evidence limits and safety points stated for this botanical or ingredient.
Change history
| Date | Change | Clinical-review status |
|---|---|---|
| 6 September 2026 | Source-linked reference published | Pending |
Keep a private record
UpgradeYourself lets you keep private records of routines and observations you choose to discuss with a qualified health professional. This reference does not recommend starting, stopping or changing an item.