Supplement reference
Alpha-Lipoic Acid
A sourced reference on Alpha-Lipoic Acid identity, evidence limits and safety context.
Source and review status
Published sources checked
Sources checked on: 6 September 2026
Qualified clinical review: Pending. This page has not been clinically reviewed.
About this source check
AI-assisted editorial source checking covers the cited material and its stated limits. It is not a systematic review, verification of a supplied product, or clinical sign-off.
Editorial role: InfoAddict. Last material change: 6 September 2026. Next source review: 6 March 2027.
What it is
Alpha-lipoic acid is a naturally occurring short-chain fatty acid. Supplement products contain amounts that differ from food exposure.
Sources: National Library of Medicine, PubMed
What the cited evidence shows
A 2019 meta-analysis pooled 11 controlled adult trials of alpha-lipoic acid and lipid measures. It reported changes in triglycerides, total cholesterol and LDL cholesterol, but study populations and protocols varied. These biomarker findings do not establish cardiovascular benefit or a treatment recommendation.
Sources: National Library of Medicine, PubMed
Limits and safety context
The cited lipid review is not an interaction guide. This reference gives no dose or self-management plan for diabetes, neuropathy or lipid conditions.
Sources: National Library of Medicine, PubMed
Published sources
- Effect of alpha-lipoic acid supplementation on lipid profile: a systematic review and meta-analysis
National Library of Medicine, PubMed. 2019; accessed 6 September 2026.
Supports: Eleven controlled clinical trials in adults, with heterogeneous lipid outcomes; not a universal metabolic-treatment conclusion.
Change history
| Date | Change | Clinical-review status |
|---|---|---|
| 6 September 2026 | Source-linked reference published | Pending |
Keep a private record
UpgradeYourself lets you keep private records of routines and observations you choose to discuss with a qualified health professional. This reference does not recommend starting, stopping or changing an item.